In a special review, Gustavo Deco et al. present a key reference work which explores the computational approaches that have been used to characterize the dynamics of the cortex at all levels. This article has an accompanying Editorial.
Ragan, Littlejohn and Ross provide the latest snapshot of bioinformatic and computational genome-scale biology across the globe, this time Down Under.
Now available! Read the entire Developing Computational Biology Collection
The authors take a fresh approach to the study of DNA-protein interactions, balancing protein-centric and DNA-centric points of view. Their methods identify key clusters of interacting residues and hubs, and provide deeper insight into the analysis of protein-DNA recognition mechanisms.
Using a detailed biophysical model of the cochlea, Kern et al. investigate the possibility of using microsurgery to tune regions of the ear so that malfunctioning portions are circumvented by relaying the signal to areas of normal functionality.
The authors use a biologically plausible model to investigate the mechanisms and conditions leading to effective rehabilitation following stroke. They find that if spontaneous arm use is above a certain threshold it will reinforce further improvement, and training can be stopped.
PLoS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is the official journal of the International Society for Computational Biology.
E-mail Alerts
RSS (What is RSS?)
Join PLoSRead the PLoS Blog 
and contribute your views on scientific research and open-access publishing.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
